# Mamidi Health — AIVA

> AIVA is an AI clinical analyst for genomic diagnostics. It interprets whole genomes — SNVs/Indels, copy number variants (CNVs), structural variants (SVs), and pharmacogenomics — delivering ACMG/AMP-compliant, phenotype-aware results in hours instead of weeks. Built for clinical and research labs that want faster, cheaper, accurate variant interpretation without expert bottlenecks.

Key facts about the platform:

- AIVA accelerates rare disease interpretation from 4+ weeks of manual review to roughly 10 minutes from annotated sample to insights.
- Variant classification is benchmarked at 90%+ pathogenic sensitivity on the FDA-approved ClinGen eRepo dataset (8,387 curated variants), powered by a 4M+ connection knowledge graph (AIVA-KG) covering all 28 ACMG/AMP evidence codes.
- It is pipeline-agnostic (Sarek, GATK, Dragen, DeepVariant, nf-core/raredisease, Parabricks) and works with Illumina, PacBio, Oxford Nanopore, Element, and MGI sequencing data, preserving custom annotations from VEP, ANNOVAR, SnpEff, and bcftools.
- It is extensible via the Model Context Protocol (consumer and server), a REST API, and 10+ built-in genomic tools.
- Pharmacogenomics covers 88+ drug-metabolizing genes with CPIC/DPWG guideline mapping and ML-powered structural variant detection.
- Compliance: HIPAA and GDPR, BAA-backed AI infrastructure, zero-day data retention (genetic data deleted immediately after analysis, never used for model training), and automatic detection of 15+ PHI entity types.
- Live product: https://chat.aivaportal.com

## Solutions

- [Rare Disease Interpretation](https://mamidi.ai/solutions/rare-disease-interpretation): AI-powered rare disease interpretation with trio analysis, phenotype-aware ACMG classification, and 10-minute sample-to-insights turnaround.
- [Variant Classification & Interpretation](https://mamidi.ai/solutions/variant-classification): Automated ACMG/AMP variant classification with 90% pathogenic sensitivity on FDA-approved clinical data, phenotype-aware reasoning, and structured evidence tracking.
- [Pharmacogenomics (PGx)](https://mamidi.ai/solutions/pharmacogenomics): Automated star allele calling across 88+ pharmacogenes with CPIC/DPWG guideline mapping, metabolizer phenotype prediction, and prescriber-ready reporting.
- [Pipeline Integrations](https://mamidi.ai/solutions/pipeline-integrations): Pipeline-agnostic genomic analysis with Seqera Studio integration and compatibility with any sequencing platform or annotation tool.
- [Clinical Reporting & Compliance](https://mamidi.ai/solutions/clinical-reporting): One-click clinical report generation with custom templates, HIPAA/GDPR compliance, zero-day data retention, and automatic PHI detection and sanitization.
- [API & Extensibility](https://mamidi.ai/solutions/api-extensibility): Extend AIVA with MCP protocol support, REST API access, 10+ built-in genomic tools, and full programmatic automation for custom workflows.

## Blog

- [AIVA Blog](https://mamidi.ai/blogs): Articles and benchmarks on agentic genomic analysis, phenotype-aware variant classification, and gene prioritization.
- [Day 1: Your Pipeline. Your Annotations. Your Team. Zero Conversion.](https://mamidi.ai/blog-posts/day1.html): How AIVA fits into existing lab pipelines without file conversion or lost annotations.
- [Day 2: Customized Variant Analysis Experience](https://mamidi.ai/blog-posts/day2.html): Tailoring variant analysis workflows to a lab's specific needs.
- [Day 3: Everything from Yesterday. Through Natural Conversation.](https://mamidi.ai/blog-posts/day3.html): Driving genomic analysis through natural language queries.
- [Day 4: AIVA Isn't Just a Chatbot. It's More Than That.](https://mamidi.ai/blog-posts/day4.html): AIVA as an agentic clinical analyst with specialized genomics tools.
- [Day 5: Reporting and Security](https://mamidi.ai/blog-posts/day5.html): Clinical report generation, compliance, and data security.

## Company

- [Contact](https://mamidi.ai/contact): Request a demo or get in touch with the Mamidi Health team.
- [Privacy Policy](https://mamidi.ai/privacy-policy): How Mamidi Health handles data and privacy.
- [Terms of Service](https://mamidi.ai/terms-of-service): Terms governing use of the website and AIVA.

## Optional

- [Try AIVA Live](https://chat.aivaportal.com): Interactive demo of the AIVA platform.
- [Sitemap](https://mamidi.ai/sitemap.xml): Full XML sitemap of all indexed pages.