AIVA (AI-assisted Variant Analysis) is an AI-powered genomic diagnostics platform designed for diagnostic labs. It acts as your AI Clinical Analyst, using 10+ state-of-the-art AI models to automate variant analysis and deliver genetic diagnoses in 5 minutes instead of weeks. AIVA combines natural language interaction with ACMG-compliant classification to eliminate expert bottlenecks, with zero data retention for complete privacy.

AIVA integrates into your existing genomic workflow after sequencing and secondary analysis. You upload your VCF files from any pipeline, and AIVA performs tertiary analysis. Through natural conversation, you can ask questions, filter variants, and get instant ACMG-compliant classifications with detailed evidence summaries. Clinical reports are generated in your lab's exact format with one click.

Who is AIVA designed for?

AIVA is built for diagnostic laboratories performing genomic testing, including clinical labs, genetic testing providers, and research institutions. It serves lab directors, genetic counselors, variant analysts, clinical specialists, and bioinformaticians who need to analyze genetic variants efficiently while maintaining clinical accuracy and regulatory compliance.

How fast is AIVA compared to traditional genetic analysis?

AIVA delivers sample-to-diagnosis in just 5 minutes. From VCF upload to clinical-grade report, what traditionally takes weeks of expert review is completed in minutes. AIVA can query 5 million variants in under 1 second, and each AI query takes less than 1 minute to search literature, query databases, and filter variants.

How long does it take to generate a clinical report with AIVA?

Clinical reports are generated instantly with AIVA. Traditional report generation takes days because analysts must manually compile findings, gather evidence, and format documentation. AIVA automates this entire process, producing custom clinical reports in your lab's exact format with one click.

How many cases can a specialist handle with AIVA?

Each specialist can handle 5-10x more cases when using AIVA. By reducing per-case analysis time from hours to minutes, AIVA allows your existing team to dramatically increase throughput without sacrificing accuracy or thoroughness. This means labs can scale their testing capacity without proportionally increasing staff.

What is ACMG/AMP variant classification?

ACMG/AMP variant classification is the gold standard framework established by the American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) for interpreting genetic variants. It categorizes variants into five classes: Pathogenic, Likely Pathogenic, Uncertain Significance (VUS), Likely Benign, and Benign. AIVA applies these criteria systematically and automatically, ensuring every classification meets clinical standards.

How accurate is AIVA's variant analysis?

AIVA ensures high accuracy through systematic application of ACMG/AMP criteria, real-time variant-disease association matching, and comprehensive evidence gathering from genomic databases and literature. Every classification includes detailed evidence summaries so analysts can verify the reasoning.

How does phenotype-aware analysis improve results?

Phenotype-aware analysis means AIVA considers the patient's clinical symptoms when classifying variants. Instead of analyzing variants in isolation, AIVA matches variant-disease associations to the patient's specific presentation. AIVA applies specific ACMG codes based on phenotype matching: PP4: Patient's phenotype highly specific for disease. PS4: Prevalence in affected vs controls. PP1/BS4: Cosegregation with disease

How much can labs save using AIVA?

Labs achieve significant cost savings with AIVA by reducing analysis time from weeks to just 5 minutes per case. These savings come from eliminating expert bottlenecks, dramatically increasing throughput without adding staff, and reducing time-to-diagnosis. By automating the most time-intensive parts of variant analysis, AIVA allows labs to process more samples with existing resources.

Why is AIVA more cost-effective than traditional methods?

Each AI query takes less than 1 minute to search literature, query databases, and filter variants. Tasks that previously took an analyst 30-60 minutes of manual searching now happen in seconds. When you multiply this across hundreds of variants per case and dozens of cases per week, the time savings translate directly into cost savings. Your team processes more cases in less time without adding headcount.

What file formats does AIVA accept?

AIVA accepts VCF (Variant Call Format) files, as well as CSV and TSV files if you've already annotated your variants with another tool. Both compressed (.gz) and uncompressed files are supported. With our optional Parabricks pipeline, you can also upload FASTQ files directly from any sequencing platform. You can upload files through the web interface or programmatically via API for automated workflows. AIVA preserves all your custom annotations throughout analysis, whether from VEP, ANNOVAR, SnpEff, or your own tools.

Can AIVA integrate with our existing sequencing pipeline?

Yes, AIVA is pipeline-agnostic. It accepts VCF files from any bioinformatics pipeline including Sarek, GATK, DeepVariant, and Dragen. There's no vendor lock-in and no need to change your existing workflows. AIVA also integrates with Seqera Studio and offers full API access for custom integrations with your laboratory information systems. Alternatively, you can use our built-in Parabricks-powered secondary analysis pipeline to go directly from FASTQ to variants.

Can AIVA process FASTQ files directly?

Yes, with our optional Parabricks-powered secondary analysis pipeline. You can upload FASTQ files from any sequencing technology—both short-read (Illumina) and long-read (PacBio, Oxford Nanopore)—and AIVA will handle the complete workflow from raw reads to clinical report. This eliminates the need for separate bioinformatics infrastructure while still allowing labs with existing pipelines to use their own VCF outputs.

Does AIVA work with WES and WGS data?

Yes, AIVA supports both Whole Exome Sequencing (WES) and Whole Genome Sequencing (WGS) data. The platform is designed to handle the variant volumes from either sequencing approach, providing the same fast, accurate analysis regardless of your sequencing strategy.

How does AIVA handle multi-sample VCF files?

AIVA natively supports multi-sample VCF files. You can upload family trios, case-control studies, or any multi-sample dataset without preprocessing. AIVA maintains sample relationships and allows you to analyze variants across samples while preserving individual sample annotations and quality metrics.

Can AIVA integrate with other AI tools using MCP?

Yes, AIVA supports Model Context Protocol (MCP) integrations in both directions. You can add external MCPs to AIVA to extend its analysis capabilities with your own tools or third-party services. You can also use AIVA as an MCP server in other AI agents like Claude Desktop, allowing you to query variants, search your genomic data, and run analyses directly from your preferred AI assistant.

Is AIVA HIPAA compliant?

Yes, AIVA is built on HIPAA-compliant infrastructure. We have BAA (Business Associate Agreement) agreements with all our cloud providers. The platform is designed from the ground up for healthcare compliance with automatic PHI detection and secure data handling.

Is AIVA GDPR compliant?

Yes, AIVA is fully GDPR compliant for users in the European Union. We process data based on consent, contractual necessity, and legitimate interests. Users have full rights to access, correct, delete, and port their data.

How is patient data protected in AIVA?

AIVA protects patient data through automatic PHI (Protected Health Information) detection to prevent accidental exposure and secure data handling practices. All infrastructure is designed to meet healthcare compliance requirements including HIPAA and GDPR, ensuring patient information remains protected at every step.

What training is needed to use AIVA?

Minimal training is required to use AIVA. The platform uses a natural conversation interface, so if you can describe what you're looking for, AIVA understands. There are no complex interfaces to learn or specialized query languages to master. Analysts can ask questions in plain language and get immediate, actionable results. Most users become productive within their first session.

Can we customize AIVA for our lab's workflow?

Yes, AIVA is highly customizable. You can configure the interface to show only relevant annotations, create custom clinical reports in your lab's exact format, and integrate custom tools using the Model Context Protocol (MCP). With 10+ built-in genomic tools and full API access, AIVA adapts to your workflow rather than forcing you to change how you work.

Privacy Policy

Last updated: January 2026

Introduction

Mamidi Health ("we", "our", or "us") is committed to protecting your privacy. This Privacy Policy explains how we collect, use, disclose, and safeguard your information when you visit our website or use our services.

Please read this Privacy Policy carefully. If you do not agree with the terms of this Privacy Policy, please do not access our website or use our services.

Information We Collect

We may collect information about you in a variety of ways:

Personal Data

We may collect personally identifiable information, such as your name, email address, phone number, and medical history when you register for our services, sign up for our newsletter, or contact us. This information is collected with your consent and is necessary for us to provide our services, including those related to genetic diseases.

Genetic Data

When you use our genetic analysis services, we collect and process genetic samples and related data. This is highly sensitive information that we handle with the utmost care and security.

Usage Data

We may also collect information on how our website is accessed and used. This usage data may include information such as your computer's Internet Protocol address, browser type, browser version, the pages of our website that you visit, the time and date of your visit, the time spent on those pages, and other diagnostic data.

How We Use Your Information

We may use the information we collect from you for the following purposes:

To provide and maintain our services
To notify you about changes to our services
To allow you to participate in interactive features of our services
To provide customer support
To gather analysis or valuable information so that we can improve our services
To monitor the usage of our services
To detect, prevent, and address technical issues
To provide you with news, special offers, and general information about other services and events we offer

Data Security

The security of your data is important to us. We implement appropriate security measures to protect your personal information from unauthorized access, alteration, disclosure, or destruction. We use advanced encryption technologies and HIPAA-compliant infrastructure to handle your data.

However, please be aware that no method of transmission over the Internet or method of electronic storage is 100% secure. While we strive to use commercially acceptable means to protect your personal information, we cannot guarantee its absolute security.

Data Retention

We practice zero-day data retention for genetic analysis data. Your genetic data is processed in real-time and permanently deleted immediately after analysis is complete. We do not store genetic samples or analysis results on our servers beyond the active session.

Personal information (such as contact details) may be retained as necessary to provide our services, comply with legal obligations, resolve disputes, and enforce our agreements.

HIPAA Compliance

For users in the United States, we comply with the Health Insurance Portability and Accountability Act (HIPAA). We implement appropriate administrative, physical, and technical safeguards to protect the privacy and security of protected health information (PHI).

We maintain Business Associate Agreements (BAA) with our cloud service providers and follow strict protocols for handling health information.

GDPR Compliance

For users in the European Union, we comply with the General Data Protection Regulation (GDPR). We process your personal data based on the following lawful bases:

Consent: When you submit information through our platform
Contract: To provide our genetic analysis services
Legitimate interests: To improve our services and ensure security

You have the right to withdraw consent at any time, request access to your data, and exercise your rights under GDPR as outlined in the "Your Rights" section below.

International Data Transfers

We operate in India and the United States. Your data may be transferred to and processed in either location. We ensure appropriate safeguards are in place for international transfers in compliance with applicable data protection laws, including GDPR and other relevant regulations.

Your Rights

Under data protection laws, you have rights including:

The right to access your personal data
The right to correct any inaccurate personal data
The right to request deletion of your personal data
The right to restrict or object to our processing of your personal data
The right to data portability

To exercise any of these rights, please contact us using the information provided below.

Changes to This Privacy Policy

We may update our Privacy Policy from time to time. We will notify you of any changes by posting the new Privacy Policy on this page and updating the "Last updated" date at the top of this page.

You are advised to review this Privacy Policy periodically for any changes. Changes to this Privacy Policy are effective when they are posted on this page.

Contact Us

If you have any questions about this Privacy Policy, please contact us at tarun@mamidi.ai